منابع مشابه
Unethical Conduct of Underpowered Clinical Trials
I read with interest the article on the effect of antiseptics on the colonization rate of central venous catheters, published in the recent issue of your Journal.1 Although the topic is very important, the study suffers from many shortcomings, the most important of which is low study power. Assuming expected prevalence rates of 22% and 17% in the control and treatment groups (an effect size of ...
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متن کاملThe continuing unethical conduct of underpowered clinical trials.
Despite long-standing critiques of the conduct of underpowered clinical trials, the practice not only remains widespread, but also has garnered increasing support. Patients and healthy volunteers continue to participate in research that may be of limited clinical value, and authors recently have offered 2 related arguments to support the validity and value of underpowered clinical trials: that ...
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ژورنال
عنوان ژورنال: Academic Medicine
سال: 1998
ISSN: 1040-2446
DOI: 10.1097/00001888-199811000-00004